PKM2, a Central Point of Regulation in Cancer Metabolism
نویسندگان
چکیده
منابع مشابه
PKM2, a Central Point of Regulation in Cancer Metabolism
Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the demands of proliferation. The M2 isoform of pyruvate kinase (PKM2) catalyzes the final and also a rate-limiting reaction in the glycolytic pathway...
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Cancer cells have distinct metabolism that highly depends on glycolysis instead of mitochondrial oxidative phosphorylation alone, known as aerobic glycolysis. Pyruvate kinase (PK), which catalyzes the final step of glycolysis, has emerged as a potential regulator of this metabolic phenotype. Expression of PK type M2 (PKM2) is increased and facilitates lactate production in cancer cells, which d...
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ژورنال
عنوان ژورنال: International Journal of Cell Biology
سال: 2013
ISSN: 1687-8876,1687-8884
DOI: 10.1155/2013/242513